In response to the rapidly increasing HIV/AIDS pandemic in the region, the independent, non-governmental Regional Knowledge Hub for the Care and Treatment of HIV/AIDS in Eurasia was established in 2004 and is supported by Deutsche Gesellschaft fur Technische Züsammenarbeit (GTZ) and the World Health Organization's Regional Office for Europe (WHO/Euro) in conjunction with the American International Health Alliance (AIHA).

Based at the Odessa Oblast Hospital and established in June 2003, the Southern Ukraine AIDS Education Centre (SUAEC) uses a hands-on, team-based approach to train physicians, nurses, and other professionals involved in the care and treatment of HIV/AIDS. The Centre's expertise lies in the prevention of mother-to-child transmission (PMTCT) of HIV, pediatric HIV/AIDS, and the prevention of occupational exposure. In 2003, SUAEC was named a WHO
Centre of Excellence.

In 2006, the American International Health Alliance (AIHA)—in conjunction with the St. Petersburg Medical Academy for Post Graduate Studies and affiliated clinical sites at the St. Petersburg AIDS Center and the Ust Izhora Clinical Center for Children and Women with HIV—has established an AIDS Training and Education Center (ATEC) in Saint Petersburg, Russia. This project, which was developed with funding from the United States Agency for International Development (USAID) and supported by the Russian Federation Ministry of Health and Social Development, represents a key step in the development of a unified framework for Russia’s national efforts to build the health system capacity necessary to provide high-quality care to people living with HIV/AIDS (PLWHA).